• Video.
• Summary

• All Multiple Endocrine Neoplasia (MEN) syndromes exhibit autosomal dominant inheritance.
• A way to remember this is "All MEN are dominant" (or so they think).
• MEN refer to a group of familial disorders marked by specific clusters of endocrine abnormalities.

MEN 1

▪ Parathyroid tumors ▪ Pituitary tumors (prolactin or GH) ▪ Pancreatic endocrine tumors: Zollinger- Ellison syndrome, insulinomas, VIPomas, glucagonomas (rare). ▪ Associated with mutation of MEN1 gene (menin, a tumor suppressor).

<aside> 🧠 MEN 1 = 3 P’s: Pituitary, Parathyroid, and Pancreas.

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MEN 2A

▪ Pheochromocytoma (episodic headache). ▪ Parathyroid hyperplasia. ▪ Medullary thyroid carcinoma (secretes calcitonin). ▪ Mutation in RET gene (codes for receptor tyrosine kinase).

<aside> 🧠 MEN 2A = 2 P’s: Parathyroids and Pheochromocytoma.

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MEN 2B

▪ Pheochromocytoma (episodic headache). ▪ Medullary thyroid carcinoma (secretes calcitonin). ▪ Mucosal neuromas which are flesh-colored nodules on his lips and tongue (unencapsulated, thickened proliferations of neural tissue). ▪ Associated with marfanoid habitus (tall and slender with disproportionately long arms, legs, and fingers)